CONICET fellowships call 2015
positions are offered to apply for doctoral or postdoctoral fellowship from CONICET in the call of this year
General requirements for applicants
– doctoral fellowship: be a graduate or student received very next race of Chemical Sciences, Biology, Biotechnology, or related. preferably, but not exclusive, with overall higher than 7,50. Send CV with qualifications obtained during the course, including aplazos.
– Beca postdoctoral: possess a doctorate degree in Chemistry, Biological or related field or certify completion before 1 April 2016. Send full CV detailing the theme of Doctoral Thesis.
For customized and more information on research topics, contact Principal Investigators
Research topics
genetic and epigenetic control of stress tolerance mediated by DNA glycosidase Arabidopsis MBD4
Synopsis: MBD4 is a glycosidase that cleaves DNA damaged DNA bases and promotes its replacement by sound basis. in animals, the enzyme alters epigenetic marks and expression of nuclear genes. Arabidopsis contains a nuclear MBD4 expressed in special conditions and provides stress tolerance. It is proposed to study the basis of this tolerance, analyzing the effect of the enzyme on their target genes. For it, molecular biology strategies apply, biochemistry and cell biology (transcriptoma, chromatin marks, microscopia confocal, etc.) to characterize the response of plants with abnormal expression of MBD4 under stress.
responsible researcher: Dr. Maria Elena Alvarez
Position Type: Doctorate, Postdoctorado
Contact us: malena@mail.fcq.unc.edu.ar
Posttranslational modifications tubulin regarding the genesis of neuronal pathologies
Synopsis: tubulin, protein constituent of microtubules (MTs), after their synthesis, undergoes changes (posttranslational) that can modify their structure and / or behavior. Since MTs involved in critical events such as cell division (MTs form the mitotic spindle) and intracellular transport (MTs serve “roads” on which molecular motors carrying destination charge move), We hypothesize that the post-translational modification of tubulin can modify the behavior of MTs and thus generate alterations in the normal functioning of neurons. We are considering these changes in MTs are the cause of diseases such as phenylketonuria and Parkinson's disease.
Principal Investigator: Dr. Carlos A. Arce
Position Type: Doctorate, Postdoctorado
Contact us: caecra@dqb.fcq.unc.edu.ar
Analysis of the effect of altered methylation of adenines on genetic stability and virulence Escherichia coli
Synopsis: In Escherichia coli, Salmonella and other bacteria, methylation of adenines is important for maintaining genetic stability. In addition, this methylation is involved in the regulation of gene expression of several genes, and among them, of virulence factors.
Recently in our laboratory we isolate mutants deficient in methylation process showing particular phenotypic characteristics that could be beneficial to the pathogenicity of these bacteria.
The objective of this project is to identify the mutations responsible for the phenotype, analyzing the effects on genetic stability and regulation of gene expression and elucidate / mechanisms by which some of these alterations could be beneficial for pathogenicity.
Principal Investigator: Dr. José L. Barra
Position Type: Doctorate, Postdoctorado
Contact us: jlbarra@fcq.unc.edu.ar
structural relationship(dis)function oligomers of α-synuclein amyloid
Synopsis: Amyloid aggregation of α-synuclein protein (AS) It is the common denominator of a heterogeneous group of neurodegenerative diseases such as Parkinson's disease and multiple system atrophy. It is postulated that prefibrilares oligomers would be the most neurotoxic species. The overall objective of the project is to understand the relationship structure-(dis)function AS oligomers focus on the study of the structure and supramolecular organization of such species, interaction model systems and its relationship biological membranes with the membrane permeabilization and spread of disease. For this molecular biological techniques be used, optical spectroscopy, single molecule techniques, microscopies and tests at the cellular level.
responsible researcher: Dr. M. Soledad Celej
Position Type: Doctorate, Postdoctorado
Contact us: mcelej@mail.fcq.unc.edu.ar
Circadian regulation and Stress Granules Processing Bodies
Synopsis: Circadian Rhythms are biological functions that vary cyclically with time 24h. They are generated internally by biological mechanisms called watches. These regulate a large number of variables; from the behavior through cellular functions and gene expression. Between 5 and the 30% genes are expressed rhythmically. In our laboratory we study the circadian regulation of cytoplasmic RNA granules, Stress Granules Processing and Bodies. They are added ribonucleoprotein microscopically visible where messengers are translationally silenced. Both structures are involved in the metabolism of Transcripts (mRNA) in the cytoplasm to play a role in the regulation of translation, stability and stored messengers.
Principal Investigator: Dr. Eduardo Garbarino Pico
Position Type: Doctorate
Contact us: garba@fcq.unc.edu.ar
mechanical properties of lipid membranes. Effect of the composition of the membrane and middle
Synopsis: The plasma membrane is a highly specialized organelle regulating the entry and exit of various molecules with high selectivity, In addition to serving as a platform for various signaling complexes. To fulfill its functions, the mechanical properties of the plasma membrane must be specific: They are not completely rigid, but not too soft, presenting a viscoelastic behavior.
The general objective in the thesis be framed is to understand how the mechanical properties of cell membranes to regulate changes in the lipid composition of the membrane, protein structure, cytoskeleton and interactions with the.
responsible researcher: Dr. Natalia Wilke
Position Type: Doctorate
Contact us: natiwilke@gmail.com