By Dr. Alfredo Caceres, INIMEC-CONICET-UNC-IUCBC
Next Wednesday 13 of April, to 11 hours, in the Auditorium of the Scientific Technological Center of Cordoba (CCT) will begin a new cycle of External Researchers Conference "CIQUIBIC Open Door".
The inaugural lecture will be delivered by Dr. Alfredo Caceres, Superior CONICET researcher, Director of the Laboratory of Neurobiology Medical Research Institute Mercedes and Martin Ferreyra (INIMEC-CONICET) and Professor at the Institute of Biomedical Sciences of Córdoba (IUCBC), where it serves as Vice Dean.
The multiple functions of RhoA in neuronal polarization
RhoA, a conspicuous member of the family of small RhoGTPases has been implicated in neuronal development. It has been proposed that RhoA and its canonical downstream effector Rho Kinase (ROCK) exert an inhibitory tone preventing undifferentiated neurites from engaging in axon-like growth. In this presentation I will provide evidence suggesting that RhoA exerts both inhibitory and stimulatory functions during during axon formation that differentially affect the growth cone cytoskeleton and involved two different effector proteins, namely ROCK and the formin mDia. RhoA also participates in dendrite development/maturation by promoting the biogenesis of Golgi outposts (satellite mini-Golgi apparatus) required for dendrite branching and synaptic plasticity. Together our observations suggest complex and diverse functions of RhoA during axon/dendrites formation.
Design: Jeremías Di Pietro / Graphic design CCT CONICET CORDOBA
For the opening “CIQUIBIC Open Doors” Lecture, CIQUIBIC is pleased to welcome Dr. Alfredo Caceres, CONICET Senior Researcher at the Institute for Medical Research Mercedes and Martin Ferreyra and Professor and Vice Dean at the University Institute of Biomedical Sciences in Cordoba University of Illinois in Chicago.
The conference will be held on Wednesday April 13, at 11 pm in the Auditorium of the Scientific Technological Center CONICET (CCT-Córdoba).
The multiple functions of RhoA in neuronal polarization
RhoA, a conspicuous member of the family of small RhoGTPases has been implicated in neuronal development. It has been proposed that RhoA and its canonical downstream effector Rho Kinase (ROCK) exert an inhibitory tone preventing undifferentiated neurites from engaging in axon-like growth. In this presentation I will provide evidence suggesting that RhoA exerts both inhibitory and stimulatory functions during during axon formation that differentially affect the growth cone cytoskeleton and involved two different effector proteins, namely ROCK and the formin mDia. RhoA also participates in dendrite development/maturation by promoting the biogenesis of Golgi outposts (satellite mini-Golgi apparatus) required for dendrite branching and synaptic plasticity. Together our observations suggest complex and diverse functions of RhoA during axon/dendrites formation.
Design: Jeremías Di Pietro / Graphical design CCT CONICET CÓRDOBA