A cargo del Dr. Alfredo Cáceres, INIMEC-CONICET-UNC-IUCBC
El próximo miércoles 13 de abril, a las 11 horas, en el Auditorio del Centro Científico Tecnológico de Córdoba (CCT) dará comienzo un nuevo Ciclo de Conferencias de Investigadores Externos “CIQUIBIC de Puertas Abiertas”.
La conferencia inaugural estará a cargo del Dr. Alfredo Cáceres, Investigador Superior de CONICET, Director del Laboratorio de Neurobiología del Instituto de Investigación Médica Mercedes y Martin Ferreyra (INIMEC-CONICET) y Profesor del Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), en donde se desempeña como Vice Decano.
The multiple functions of RhoA in neuronal polarization
RhoA, a conspicuous member of the family of small RhoGTPases has been implicated in neuronal development. It has been proposed that RhoA and its canonical downstream effector Rho Kinase (ROCK) exert an inhibitory tone preventing undifferentiated neurites from engaging in axon-like growth. In this presentation I will provide evidence suggesting that RhoA exerts both inhibitory and stimulatory functions during during axon formation that differentially affect the growth cone cytoskeleton and involved two different effector proteins, namely ROCK and the formin mDia. RhoA also participates in dendrite development/maturation by promoting the biogenesis of Golgi outposts (satellite mini-Golgi apparatus) required for dendrite branching and synaptic plasticity. Together our observations suggest complex and diverse functions of RhoA during axon/dendrites formation.
Diseño: Jeremías Di Pietro / Diseño Gráfico CCT CONICET CÓRDOBA
For the opening “CIQUIBIC Open Doors” Lecture, CIQUIBIC is pleased to welcome Dr. Alfredo Cáceres, CONICET Senior Researcher at the Institute for Medical Research Mercedes and Martin Ferreyra and Professor and Vice Dean at the University Institute of Biomedical Sciences in Cordoba University of Illinois in Chicago.
The conference will be held on Wednesday April 13, at 11 pm in the Auditorium of the Scientific Technological Center CONICET (CCT-Córdoba).
The multiple functions of RhoA in neuronal polarization
RhoA, a conspicuous member of the family of small RhoGTPases has been implicated in neuronal development. It has been proposed that RhoA and its canonical downstream effector Rho Kinase (ROCK) exert an inhibitory tone preventing undifferentiated neurites from engaging in axon-like growth. In this presentation I will provide evidence suggesting that RhoA exerts both inhibitory and stimulatory functions during during axon formation that differentially affect the growth cone cytoskeleton and involved two different effector proteins, namely ROCK and the formin mDia. RhoA also participates in dendrite development/maturation by promoting the biogenesis of Golgi outposts (satellite mini-Golgi apparatus) required for dendrite branching and synaptic plasticity. Together our observations suggest complex and diverse functions of RhoA during axon/dendrites formation.
Design: Jeremías Di Pietro / Graphical design CCT CONICET CÓRDOBA