Lic. Guendulain conduct a stay in Germany
Lic. Tatiana Guendulain was awarded with a fellowship from the University of Regensburg and the German Academic Exchange Service (DAAD), through the iPUR program (International PhD program at the University of Regensburg), for a 3-month stay in the laboratory of Prof. Dr. Werner Kremer, at the Institute of Biophysics and Physical Biochemistry, College of Biology and Preclinical Medicine, University of Regensburg, Germany.
Tatiana is doing her PhD thesis under the supervision of Dr. José Luis Barra. She seeks to generate complementary therapies for the treatment of trimethylaminuria, a rare metabolic disorder characterized by the accumulation of trimethylamine (TMA) in the body, which is released in different body fluids. Normally, the TMA is oxidized to trimethylamine N-oxide (TMAO) by the action of the enzyme flavin monooxygenase. When the enzyme does not work properly, the body loses the ability to transform TMA, a highly volatile, fish-smelling compound, into the odorless compound TMAO. Therefore, to characterize this enzyme is of interest to be able to use it in complementary therapies for such metabolic disorder. Tatiana will express flavin monooxygenase in bacteria and during her stay in Germany she will analyze the folding and stability of the enzyme using different variants of the nuclear magnetic resonance (NMR) and dynamic light scattering (DLS) technique.