Independent Researcher CONICET / Associate Professor (DS) UNC
Phone:+54 351 5353855 ext 3465
Biophysics of biological processes associated to protein/lipid interactions: a systematic study of the interaction of amphiphilic peptides and proteins with biological model interfaces
In the cell, the transport and recycling of components and organelles is due to the specific interaction between proteins and lipid membranes or organelles that have a characteristic structure and composition. What are the physical parameters that control this membrane / protein interaction and how the structure of organelles maintained / generated as a result of this relationship are fundamental questions both in the area of biophysics and in cell biology. The overall objective in my research is to understand the physicochemical properties of the protein interaction with biological membranes analyzing how the variability in the chemistry of proteins and / or peptides (primary structure) and physical properties of lipid membrane models (phase-state, membrane curvature, etc) modulate the interaction. From these biophysical, experimental and theoretical studies will be applied to understand how different physicochemical properties of protein / membrane system influence or determine the organization and functioning of different organelles / cell processes.
- Luis Benito Perez Socas. Fellow CONICET.
- Ambroggio EE, Sillibourne J, Antonny B, JB Manneville, Goud B. Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. PLoS One. 2013 Apr 29;8(4):e62963.
- And ambroggio, Sorre B, Bassereau P, Goud B, JB Manneville, Antonny B. ArfGAP1 generates an Arf1 gradient on continuous lipid membranes displaying flat and curved regions. EMBO J. 2010 Jan 20;29(2):292-303.
- Ambroggio EE, Separovic F, Bowie JH, Fidelio GD, Bagatolli LA. Direct visualization of membrane leakage induced by the antibiotic peptides: maculatin, citropin, and aurein. Biophys J. 2005 Sep;89(3):1874-81.
- Ambroggio EE, Kim DH, Separovic F, Barrow CJ, Barnham KJ, Bagatolli LA, Fidelio GD. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. 2005 Apr;88(4):2706-13.
- Ambroggio EE, Separovic F, Bowie J, Fidelio GD. Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin. Biochim Biophys Acta. 2004 Jul 1;1664(1):31-7.
- Jean-Marie Ruysschaert and Vincent Raussens-Structural Biology and Bioinformatics Centre (BCBS) Structure and Function of Biological Membranes (SFMB) Universite Libre de Bruxelles, Belgium
- Patricia Bassereau-Institut Curie-Paris-France-Research Center Physical Chemistry Laboratory (UMR CNRS 168)
- Soledad Celej-CIQUIBIC-CONICET-Argentina
- Gerardo Fidelio-CIQUIBIC-CONICET-Argentina
- Hugo Maccioni-CIQUIBIC-CONICET-Argentina
- Javier Valdez-Tauber-CIQUIBIC-CONICET-Argentina
- Laura Fanani-CIQUIBIC-CONICET-Argentina
- FONCyT-PICT 2012-1377
- CONICET PIP 2013
- 2007-Ph.D. in Chemical Sciences-National University of Córdoba-College of Chemistry
- 2001-Bachelor in Chemical Sciences-National University of Córdoba-College of Chemistry
- Research Career of CONICET member at CIQUIBIC-CONICET-Extra. Qca. Biological-FCQ-UNC
- Postdoctoral studies at the Curie institute in Dr. Bruno Goud’s laboratory under supervision of Dr. Bruno Goud. Main subject of study: “Behavior of Arf1, ArfGAP1, ALPS and the COPI coatomer complex when interact with model membranes” (April 2007-March 2010).
- Postdoctoral position (visiting Fellow) at NIH (National Institutes of Health-Bethesda-USA) under the supervision of Dr. Jennifer Lippincott-Schwartz. Main subject of study: “Nanoscale distribution of proteins in cells” (October 2010-‐December 2011).
- Assistant professor at the College of Chemical Sciences-National University of Córdoba-Argentina