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Energetics of the Phase Transition in Free-standing versus Supported Lipid Membranes

Mangiarotti A et al. 2015, J. Phys. Chem. B

We compared the thermodynamic behavior of supported and free-standing films of phospholipids with different chain length and showed that the change in free energy for the phase transition to a denser state was greater in free-standing than in supported membranes, with the differences being independent of the chain length. The presence of the support promoted a decrease in the energy gap between the coexisting phases of 1.7 kJ mol-1, and this was a long-range effect affecting both leaflets, probably related with the impediment of out- of-plane motion of the film by the solid surface.

Autores: Mangiarotti A, Wilke N.

Artículo: Mangiarotti A et al., J. Phys. Chem. B, 2015, 119:8718-8724