SOSA, Lucas

Investigador Asistente de CONICET / Profesor Asistente UNC
Director: Dr. Santiago Quiroga
Teléfono: +54-351-5353855 int 3462
E-mail: lucas@fcq.unc.edu.ar

Tema de Investigación

Regulation of adhesion proteins traffic by specific rabs proteins and its implication during brain development

The amyloid precursor protein (APP) is a transmembrane glycoprotein very well known for its participation in the pathogenesis of the Alzheimer disease as a source of the amyloid beta fragment. Its physiological role in neurodevelopment has been recently elucidated indicating that APP is a cell adhesion molecule that works as a contact guidance molecule in the axonal growth cone of developing neurons, which is also involved in the migration of neurons in the cortical plate during development. However, little is known about APP traffic regulation in the neurons and how important is the control of its surface expression in the plasma membrane for neuronal migration and guidance in the developing brain. The rabs proteins are largely known key regulators of membrane trafficking, being able to control transport, tethering and docking through their different effectors. There are more than 60 RabGTPases described in mammals, from which rab35 and rab21 emerge as a possible candidates to participate in the APP traffic because they have been previously reported to play a role in neurite outgrowth, migration and traffic of others cell adhesion molecules in neurons.
In this context we propose that selected rabs proteins are involved in the surface regulation of APP in the neuron plasmmalema and, consequently, modulate the adhesion properties of APP and its role in neuronal migration during brain development.

Publicaciones Seleccionadas

• Laurino, X. X. Wang, B. A. de la Houssaye, L. Sosa, S. Dupraz, A. Caceres, K. H. Pfenninger, and S. Quiroga. 2005. PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone. J Cell Sci 118:3653-3662.
• Sosa, S. Dupraz, L. Laurino, F. Bollati, M. Bisbal, A. Caceres, K. H. Pfenninger, and S. Quiroga. 2006. IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity. Nat Neurosci 9:993-995.
• Dupraz, D. Grassi, M. E. Bernis, L. Sosa, M. Bisbal, L. Gastaldi, I. Jausoro, A. Caceres, K. H. Pfenninger, and S. Quiroga. 2009. The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons. J Neurosci 29:13292-13301.
• J. Sosa, J. Bergman, A. Estrada-Bernal, T. J. Glorioso, J. M. Kittelson, and K. H. Pfenninger. 2013. Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. PLoS One 8:e64521.
• J. Sosa, N. L. Postma, A. Estrada-Bernal, M. Hanna, R. Guo, J. Busciglio, and K. H. Pfenninger. 2014. Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. FASEB J 28:195-205.

(Ver más publicaciones-CONICET)

Colaboraciones

• Dr. James Malter. University of Texas Southwestern Medical Center.USA.
• Dr. Santiago Quiroga, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, CIQUIBIC-CONICET Argentina

Breve Currículum Vitae

Formación Académica

• Médico Cirujano egresado el 5 de agosto del año 2003, de la Facultad de Ciencias Médicas de la UNC, Argentina.
• Doctor en Ciencias Químicas. Otorgado por la Universidad Nacional de Córdoba. Aprobado el 9 de Agosto de 2007.
• Título de la tesis: “Participación del receptor de IGF-1 que contiene bgc en el establecimiento inicial de la polaridad de neuronas de hipocampo”. Calificación: Sobresaliente.

Antecedentes de Investigación
Posiciones previas

• Postdoctoral Fellow. University of Colorado School of Medicine at Denver Anschutz Medical Campus, Department of Pediatrics, The Colorado Intellectual & Developmental Disabilities Research Center (IDDRC). Laboratorio Dr. Karl Pfenninger (2008-2013).
• Postdoctoral Fellow. University of Colorado School of Medicine at Denver Anschutz Medical Campus, Department of Pediatrics, Hematology, Oncology and BMT. Laboratorio Dr. Jorge Di Paola. (2013).
• Beca Interna Posdoctoral de Reinserción CONICET. Director: Dr. Santiago Quiroga. Centro de Investigaciones en Química Biológica de Córdoba CIQUIBIC (UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, UNC. (Diciembre 2013-Febrero 2015).

Antecedentes Docentes

• Profesor Asistente DS por consurso, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. A partir del 01-04-2015.
• Ayudante de 1era, con Dedicación Simple (DS) por consurso, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 01/04/2007-31/03/2009.
• Ayudante de 1era, con Dedicación Exclusiva (DE), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 01/04/2004-31/08/2004.
• Jefe de Trabajos Prácticos, (DSE) Departamento de Química Biológica, de la Facultad de Ciencias Químicas de la Universidad Nacional de Córdoba, 01/01/2004-31/03/2004.