Contact : +54 351 5353855




Associate Researcher CONICET
Phone: +54 351 5353855 int. 3413

Research Topic

Effect of S-nitrosylation on enzymes involved in glycogen and glucose metabolism of CNS

Several neuropathology are characterized by excessive production of nitric oxide (NO) where one of the major consequence is S-nitrosylation of protein a non-protein thiols. CNS glycogen is biosynthesized in astrocyte, where it is metabolized to lactate and it is delivered to neurons. The goal of this project consists in study the effect of S-nitrosylation on structure-function of enzymes involved in metabolism of glycogen and glucose of CNS as hexokinase, triosephosphate isomerase, aldolase, glycogen synthase and glycogen phosphorylase.

Selected publications

  • Carrizo ME, Romero JM, Issoglio FM and Curtino JA. Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation. 2012 FEBS Lett. Feb 3;586(3):254-7.
  • Jorge Romero M, Bizzozero and Oscar A. Intracellular glutathione mediates the denitrosylation of protein nitrosothiols in the rat spinal cord. (2009) Journal of Neuroscience Research. Feb 15; 87(3):701-9.
  • Romero Jorge M., Issoglio Federico M., Mary E. Reed, and Curtino Juan A. Evidence for glycogenin autoglucosylation cessation by inaccessibility of the acquired maltosaccharide. (2008) Biochemical and Biophysical Research Communications. 2008 Oct 3;374 (4):704-8. Epub 2008 Jul 29.
  • Jorge Romero M, Bizzozero and Oscar A. Extracellular S-nitrosoglutathione, but not S-nitrosocysteine or N2O3, mediates protein S-nitrosation in rat spinal cord slices. (2006) Journal of Neurochemistry 2006 99 (4) 1299-1310.
  • Jorge Romero M, and Curtino Juan A. C-chain-bound glycogenin is released from proteoglycogen by isoamylase and is able to autoglucosylate. (2003) Biochemical and Biophysical Research Communications 2003 305 (4): 811-814.
  • Romero Jorge M., Mary E. Reed, Montich Guillermo, and Curtino Juan A. Inactivation and Thermal Stabilization of Glycogenin by Linked Glycogen. (2001) Biochemical and Biophysical Research Communications 2001 289 (1): 69-74.

(More publications-CONICET)

Brief CV

Academic Formation

  • Degree in Biological Chemistry, UNC, 1995.
  • PhD in Chemistry, UNC, 2003.
  • Postdoctoral: Dep. Cell Biology and Physiology, University of New Mexico, Albuquerque, NM, USA, 2005-2007

Research Background

Present position

  • Research Career of CONICET member at CIQUIBIC-CONICET-Extra. Qca. Biological-FCQ-UNC

Teaching Background

Teaching Present

  • Assistant professor at the College of Chemical Sciences-National University of Córdoba-Argentina