CIQUIBIC-CONICET-UNC


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Integrantes

SOSA, Lucas

Investigador Asistente de CONICET / Profesor Asistente UNC
Director: Dr. Santiago Quiroga
Teléfono: +54-351-5353855 int 3462
E-mail: lucas@fcq.unc.edu.ar

Tema de Investigación

Regulation of adhesion proteins traffic by specific rabs proteins and its implication during brain development

The amyloid precursor protein (APP) is a transmembrane glycoprotein very well known for its participation in the pathogenesis of the Alzheimer disease as a source of the amyloid beta fragment. Its physiological role in neurodevelopment has been recently elucidated indicating that APP is a cell adhesion molecule that works as a contact guidance molecule in the axonal growth cone of developing neurons, which is also involved in the migration of neurons in the cortical plate during development. However, little is known about APP traffic regulation in the neurons and how important is the control of its surface expression in the plasma membrane for neuronal migration and guidance in the developing brain. The rabs proteins are largely known key regulators of membrane trafficking, being able to control transport, tethering and docking through their different effectors. There are more than 60 RabGTPases described in mammals, from which rab35 and rab21 emerge as a possible candidates to participate in the APP traffic because they have been previously reported to play a role in neurite outgrowth, migration and traffic of others cell adhesion molecules in neurons.
In this context we propose that selected rabs proteins are involved in the surface regulation of APP in the neuron plasmmalema and, consequently, modulate the adhesion properties of APP and its role in neuronal migration during brain development.

Publicaciones Seleccionadas

(Ver más publicaciones-CONICET)

Colaboraciones

Breve Currículum Vitae

Formación Académica

  • Médico Cirujano egresado el 5 de agosto del año 2003, de la Facultad de Ciencias Médicas de la UNC, Argentina.
  • Doctor en Ciencias Químicas. Otorgado por la Universidad Nacional de Córdoba. Aprobado el 9 de Agosto de 2007.
  • Título de la tesis: “Participación del receptor de IGF-1 que contiene bgc en el establecimiento inicial de la polaridad de neuronas de hipocampo”. Calificación: Sobresaliente.

Antecedentes de Investigación
Posiciones previas

  • Postdoctoral Fellow. University of Colorado School of Medicine at Denver Anschutz Medical Campus, Department of Pediatrics, The Colorado Intellectual & Developmental Disabilities Research Center (IDDRC). Laboratorio Dr. Karl Pfenninger (2008-2013).
  • Postdoctoral Fellow. University of Colorado School of Medicine at Denver Anschutz Medical Campus, Department of Pediatrics, Hematology, Oncology and BMT. Laboratorio Dr. Jorge Di Paola. (2013).
  • Beca Interna Posdoctoral de Reinserción CONICET. Director: Dr. Santiago Quiroga. Centro de Investigaciones en Química Biológica de Córdoba CIQUIBIC (UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, UNC. (Diciembre 2013-Febrero 2015).

Antecedentes Docentes

  • Profesor Asistente DS por consurso, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. A partir del 01-04-2015.
  • Ayudante de 1era, con Dedicación Simple (DS) por consurso, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 01/04/2007-31/03/2009.
  • Ayudante de 1era, con Dedicación Exclusiva (DE), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 01/04/2004-31/08/2004.
  • Jefe de Trabajos Prácticos, (DSE) Departamento de Química Biológica, de la Facultad de Ciencias Químicas de la Universidad Nacional de Córdoba, 01/01/2004-31/03/2004.

Research Topic

The physiological role of the Amyloid Precursor Protein (APP) as an adhesion molecule in the developing nervous system

The amyloid precursor protein (APP) is a type I transmembrane glycoprotein that is better known for its participation in the physiopathology of Alzheimer disease as the source of the amyloid beta fragment. Also APP, encoded in the chromosome 21 is overexpress in Down syndrome and thus may contribute to the Down syndrome associated intellectual disability. However the physiological function of the full length protein and its proteolytic fragments are still under extensive studies. APP was first described as a cell-surface receptor and in the last years a series of new evidence highlight APP as a cell adhesion molecule. My lab is focus in the physiological role of APP as cell adhesion molecule involved in the different steps of neurodevelopment such as neuronal migration, neurite outgrowth, growth cone pathfinding and synaptogenesis. Also my project is approach to the potential early implication of the disturbed adhesion properties of APP during neurodevelopment in Down syndrome and the physiopathology of Alzheimer disease.

Selected Publications

(See more publications-CONICET)

Current Grants

  • Grant from Agencia Nacional de Promoción Científica y Tecnológica (FONCYT-PRH-PIDRI-2013-0020)
  • Grant from Agencia Nacional de Promoción Científica y Tecnológica (FONCYT-PICT 2014- 2331)

Brief CV

Academic Formation

  • 2003-Graduated in Doctor of Medicine (M.D.). Faculty of Medical Sciences (National University of Córdoba). Average: 9.08 (nine with 08/100) (Scale of calification 0-10).
  • 2007-Ph.D. Doctorate in Chemistry, from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) at CIQUIBIC-CONICET, Faculty of Chemical Sciences (National University of Córdoba). Thesis title: “Participation of the βgc-IGF-1 receptor in the initial establishment of hippocampal neuronal polarity”. Advisor: Prof. Dr. Santiago Quiroga.

Research Background

  • Post-doctoral position at Department of Pediatrics and Colorado Intellectual and Developmental Disabilities Research Center, University of Colorado School of Medicine, Aurora, Colorado, USA (June 2008 to July 2013). Advisor: Prof. Dr. Karl Pfenninger.
  • Post-doctoral position in the School of Medicine, Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation at the University of Colorado Anschutz Medical Campus Aurora-Colorado, USA (August 2013 to November 2013). Advisor: Prof. Dr. Jorge Di Paola.
  • Post-doctoral position from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) at CIQUIBIC-CONICET, Faculty of Chemical Sciences (National University of Córdoba), Córdoba (X5000HUA), Argentina. (2013-2015).
  • Assistant Research position from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) at CIQUIBIC-CONICET

Teaching Background

  • Assistant professor at the College of Chemical Sciences-National University of Córdoba-Argentina