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Conferencia Inaugural del Ciclo “CIQUIBIC de puertas abiertas”

A cargo del Dr. Alfredo Cáceres, INIMEC-CONICET-UNC-IUCBC

El próximo miércoles 13 de abril, a las 11 horas, en el Auditorio del Centro Científico Tecnológico de Córdoba (CCT) dará comienzo un nuevo Ciclo de Conferencias de Investigadores Externos “CIQUIBIC de Puertas Abiertas”.
La conferencia inaugural estará a cargo del Dr. Alfredo Cáceres, Investigador Superior de CONICET, Director del Laboratorio de Neurobiología del Instituto de Investigación Médica Mercedes y Martin Ferreyra (INIMEC-CONICET) y Profesor del Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), en donde se desempeña como Vice Decano.

The multiple functions of RhoA in neuronal polarization

RhoA, a conspicuous member of the family of small RhoGTPases has been implicated in neuronal development. It has been proposed that RhoA and its canonical downstream effector Rho Kinase (ROCK) exert an inhibitory tone preventing undifferentiated neurites from engaging in axon-like growth. In this presentation I will provide evidence suggesting that RhoA exerts both inhibitory and stimulatory functions during during axon formation that differentially affect the growth cone cytoskeleton and involved two different effector proteins, namely ROCK and the formin mDia. RhoA also participates in dendrite development/maturation by promoting the biogenesis of Golgi outposts (satellite mini-Golgi apparatus) required for dendrite branching and synaptic plasticity. Together our observations suggest complex and diverse functions of RhoA during axon/dendrites formation.

Diseño: Jeremías Di Pietro / Diseño Gráfico CCT CONICET CÓRDOBA